9.00AM - 3.00PM EST | 6.00AM - 12.00PM PST

8:50 am Chair’s Opening Remarks

Accelerating the Adoption of Biocatalytic Approaches in Small Molecule Manufacturing

9:00 am Panel: Biocatalysis for a Sustainable Pharma Future

Synopsis

• Improving the productivity and the quality of APIs and intermediates, whilst also achieving cost savings and greater sustainability.

• What evidence is there that biocatalysis is advantageous over traditional catalytic manufacturing methods

9:30 am From Early Phase To Full Scale Manufacturing, An Overview Of Biocatalysis At Novartis Pharma

Synopsis

  • Overview of biocatalysis on large pharma: through early-phase projects up to full-scale manufacturing.
  • Gain insight into considerations on enzyme evolution.

10:00 am Accelerating The Adoption of Biocatalysis In the Pharmaceutical Industry

  • Doug Fuerst Director - Technology Development & Synthetic Biochemistry Leader, GlaxoSmithKline

Synopsis

• Explore strategies for early adoption of enzymes in pharmaceutical routes

• Analyze modern techniques to identify novel enzyme starting points from existing genetic diversity and computational design

• Evaluate rapid directed evolution approaches to optimize enzymes for early phase pharmaceutical applications

10:30 am Morning Break

Enabling Commercially Viable and Sustainable Biocatalysis API Manufacturing

11:00 am A Sustainable Biocatalytic Process for Manufacturing a Key API Starting Material

11:30 am Enzyme Engineering to Enable an Efficient & Sustainable Biocatalytic Process

12:00 pm Novel Thermophilic Biocatalysts with Applications for Industrial Biotechnology

  • Jennifer Littlechild Professor - Biological Chemistry & Director - Exeter Biocatalysis Centre Biological Chemistry, University of Exeter

Synopsis

  • Learn the importance of enzyme stability for applied biocatalysis
  • Explore the identification, and biochemical and structural characterization of novel enzymes from Thermophilic Genomes and Metagenomes
  • Uncover Transaminases, Carboxyl Esterases, and Epoxide Hydrolases with specific industrial applications as drug intermediates

12:30 pm Efficient BVMO-Catalyzed Enantioselective Sulfoxidation for API Production: From Assay Miniaturization to Rationally Guided Engineering

Synopsis

  • Learn about assay design
  • Discuss rational enzyme engineering
  • Discuss process development

1:00 pm Networking Break

Optimizing Biotransformation Manufacturing Processes

2:00 pm Development of a Fast Organic Extraction-Precipitation Method for Enhanced Purification of Functional Elastin-like Polypeptides

Synopsis

  • Explore a highly time and material-efficient method that has been developed for purifying a broad range of elastin-like polypeptide (ELP) constructs
  • Learn how this method has been shown to be effective for purifying several different ELP fusions whose functionality has been retained
  • Assess how in addition to the greatly reduced effort and cost of this purification strategy, this technique can reduce lipopolysaccharide contamination to levels that enable in vivo experiments with the isolated ELP construct

2:30 pm Bioprocess Intensification by Non-Conventional Reaction Conditions

  • Andreas Liese Professor, Head of Institute of Technical Biocatalysis, Hamburg University of Technology

Synopsis

• Learn how to increase of sustainability in lipase catalyzed esterification in 2-in-1 deep eutectic solvents
• Explore enhanced biocatalysts stability in oxidoreductases utilizing oxygen in fine bubbles airated systems
• Assess how to shift reaction equilibrium of decarboxylase catalyzed carboxylation in airated systems, and aldolase catalyzed carbohydrate synthesis by pressure

Application of Emerging Reaction Classes in Industrial Manufacturing

3:00 pm Development of Novel Enzymatic Cascade in Molnupiravir Synthesis

3:30 pm Chair’s Closing Remarks & End of Conference