Biocatalytic Toolbox for Site-Selective Insulin Modification
Time: 3:10 pm
day: Day One
Details:
- Outline the efforts on developing a general enzymatic method to chemoselectively functionalize insulin to enable the discovery and commercial manufacturing of novel insulin therapeutics
- Explore how to use enzyme evolution to evolve from a single enzyme parent, a “toolbox” of highly active and selective amidation enzymes that enable chemists to construct insulin analogs without laborious chromatographic purification
- Evaluate how the enzymes from the toolbox were applied to large scale synthesis of a preclinical candidate to demonstrate application for commercial manufacturing
Speakers:
Chihui An completed his PhD in Chemistry at University of Pennsylvania where he completed the total synthesis of Irciniastatin B and it’s analogues to probe the molecule’s biological activity. Afterwards, Chihui was an NIH Ruth Kirchstein Postdoctoral fellow where he utilized protein engineering to reprogram Sortase A to modify disease associated proteins. In 2016, he joined Merck as a member of the Biocatalysis group and is currently…Read more