Late-Stage Chemoenzymatic Modifications of an FDAApproved Antibiotic

Time: 1:30 pm
day: Day One

Details:

  • Uncover how Indole prenyltransferase (IPT) enzymes catalyze the transfer of prenyl groups from a native prenyl pyrophosphate donor to an indole-derived acceptor
  • Explore how IPTs have interesting promiscuity in terms of donors and acceptors allowing them to catalyze late-stage modifications of compounds.
  • Learn how to use a chemoenzymatic method involving different pyrophosphate substrates and IPTs to synthesize derivatives of an FDA-approved antibiotic, and how this makes derivatives possess superior antimicrobial activity compared to the parent compound.

Speakers: