Late-Stage Chemoenzymatic Modifications of an FDAApproved Antibiotic
Time: 1:30 pm
day: Day One
Details:
- Uncover how Indole prenyltransferase (IPT) enzymes catalyze the transfer of prenyl groups from a native prenyl pyrophosphate donor to an indole-derived acceptor
- Explore how IPTs have interesting promiscuity in terms of donors and acceptors allowing them to catalyze late-stage modifications of compounds.
- Learn how to use a chemoenzymatic method involving different pyrophosphate substrates and IPTs to synthesize derivatives of an FDA-approved antibiotic, and how this makes derivatives possess superior antimicrobial activity compared to the parent compound.
Speakers:
Dr. Sherif Elshahawi is an Assistant Professor at the Department of Biomedical and Pharmaceutical Sciences at Chapman University School of Pharmacy (CUSP). He received his BPharm in 2000, MSc in 2006 from the University of Mississippi and PhD in 2012 from Oregon Health & Science University. He did his Postdoctoral training at the University of…Read more