Novel approaches to oligonucleotide synthesis using enzymes

Time: 10:00 am
day: Day One


  • Oligonucleotides are rapidly degraded in the body and this has driven the need for chemical innovation to modify and stabilise these structures
  • Enzymes are now seeing applications beyond small molecules, such as exploited in oligonucleotide synthesis, and biocatalytic approaches are alleviating the pressures on existing solid phase capacity and resulting in more convergent syntheses
  • This strong technology base can be applied to develop enzymatic methods for oligonucleotide synthesis resulting in improved yields and purity profiles compared to traditional methods
  • This presentation will show case how enzymes can be used in both single and double stranded oligonucleotide synthesis with unnatural and natural nucleotides as well as carrying structural modifications