Using Catalyst-Control for Selective C-Cl and C-C Bond Forming Reactions
Time: 2:00 pm
day: Day One
Details:
- Using directed evolution to change the site-selectivity of halogenases
- Substrate-activity profiling of natural and engineered halogenases
- Glycyl radical enzymes (GREs): Potentially powerful anaerobic, C-C bond-forming biocatalysts
- How has nature overcome the extreme oxygen-sensitivity of GREs?
Speakers:
Mary Andorfer completed her PhD in chemistry in 2017 in the lab of Prof. Jared Lewis at The University of Chicago. Her thesis work focused on engineering flavin-dependent halogenases for use as biocatalysts. She is currently an NIH postdoctoral fellow in the lab of Prof. Catherine Drennan at MIT where she studies oxygen-sensitive enzymes within…Read more