Company: Merck & Co
Job title: Associate Principal Scientist
Chihui An completed his PhD in Chemistry at University of Pennsylvania where he completed the total synthesis of Irciniastatin B and it’s analogues to probe the molecule’s biological activity. Afterwards, Chihui was an NIH Ruth Kirchstein Postdoctoral fellow where he utilized protein engineering to reprogram Sortase A to modify disease associated proteins. In 2016, he joined Merck as a member of the Biocatalysis group and is currently an Associate Principal Scientist in Process Chemistry.
Biocatalytic Toolbox for Site-Selective Insulin Modification 3:10 pm
Outline the efforts on developing a general enzymatic method to chemoselectively functionalize insulin to enable the discovery and commercial manufacturing of novel insulin therapeutics Explore how to use enzyme evolution to evolve from a single enzyme parent, a “toolbox” of highly active and selective amidation enzymes that enable chemists to construct insulin analogs without laborious…Read more
day: Day One